The £6.1 million Birthplace Project will restore and renovate the 11-hectare Station Road site, including the iconic Shuttle Row mill-workers' tenement.
A vibrant new museum will be built as part of the project, setting Scotland in a global context and celebrating the inspirational story of David Livingstone.
The work will also include the renewal of the historic buildings, a newly interpreted exhibition and an upgrade of visitor facilities such as the café and shop.
Dr Isabel Bruce, Chair of The David Livingstone Trust, said: "The Trust welcomes the appointment of Clark Contracts as main contractor and looks forward to work progressing swiftly on this important project to re-ignite the powerful story of David Livingstone for new generations and further strengthen the worldwide connections that Livingstone, his principles and legacy have inspired locally and globally.
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"Once complete, the Centre will become a key resource for learning about his heritage and his far-reaching impact in science, health, exploration, faith and humanitarian endeavour.
"Visitors will travel from all corners of the globe to explore his story and we believe it will ensure that the impact of David Livingstone's living legacy continues to be felt locally, nationally and internationally for future generations."
Access to the buildings at the David Livingstone Centre will be restricted during construction, but the wider site will be available for visitors to take walks and partake in leisure activities.
The Birthplace Project is jointly funded by The National Lottery through The Heritage Lottery Fund (£4.1m), the Scottish Government (£1.3m) and Historic Environment Scotland (£575,000).
Minister for Europe, Migration and International Development, Ben Macpherson added: "David Livingstone is an iconic figure to many people in Scotland, in Africa and across the world. Much of his inspirational work was underpinned by the principles of global humanitarianism and solidarity.
"That is why the Scottish Government has aided the transformation of the historic building and surrounding grounds that bear his name, with £1.375m funding. Once refurbished, the David Livingstone Centre will be a fitting venue to celebrate the important legacy of one of Scotland's national heroes."
(CM)
