Detailed proposals for the former John Brown's shipyard 'masterplan' will go before councillors on Wednesday, 23 March.
Plans for the 23 hectare site include residential, retail, commercial and leisure development, as well as building a health/care quarter.
Extensive civic and open space work would also be provided around the former fitting-out basin and along the riverside.
The 10-year projects first phase will see essential infrastructure works carried out, including repairs to quay walls and the creation of a new road layout.
The council agreed to invest £15 million to fund this phase of work in July last year.
Two new streets will be created, called Titan Boulevard and Titan View, to provide better access to the site. A new cycle route is also proposed.
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Further road improvement works would also be completed, with a new signal-controlled junction being installed on the former Boilermakers' Social Club site on Dumbarton Road.
It is expected the care home and health centre quarter will be developed after the first phase of works are completed.
In addition, over 1,000 new homes are proposed to be built along the edge of the River Clyde.
Other proposals could include a local retail unit, pub/diner and hotel concentrated around the fitting-out basin as well as along Dumbarton Road and Cart Street in the East Yard.
Finally, a public walkway around the basin would be created in addition to a number of open space green areas for residents and visitors to enjoy.
Richard Cairns, Executive Director of Infrastructure and Regeneration, said: "The Council has long-identified the Queens Quay site as a key regeneration area for West Dunbartonshire.
"This proposal offers an opportunity to build a significant number of social and private homes, as well as providing a range of other services and jobs on the site.
"The plans also include details of open spaces which would offer unrivalled views over the Clyde.
"It has been decades since this once thriving shipyard was in use and it's now up to Councillors to decide the best way forward."
It is understood the committee will be recommended to grant permission for the project, subject to a number of conditions being agreed, including ensuring a developer will contribute towards future bus services within the site.
(LM)
